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Our Research

Genomes carry genetic information. But genomes are not just abstract information: they are physically manifested as extremely long molecules that are intricately organized in the nucleus of every cell. The spatial organization of the genome is closely related to how it is accessed, regulated and activated by cellular machinery. We study this profound connection between genetic (and epigenetic) information and its physical organization.

Our research combines experimental and computational methods to gain a mechanistic understanding of how the genome encodes its organization and how this organization conveys biological function in various biological systems and diseases. Read more about our research here.

Lab News
  • We are recruiting a Lab Manager – join us!
  • Anna Golberg has won the Gutwirth Fellowship – congrats Anna!
  • We have received a short-term research grant from the Rappaport Institute!
  • Haia Khoury has completed her MSc in Biomedical Science – congrats Haia!
  • New preprint: “KMD clustering: Robust generic clustering of biological data” – read here.
  • New review paper: “Chromosome Conformation Capture and Beyond: Toward an Integrative View of Chromosome Structure and Function” – read here.
  • Tal Feld has completed his MSc in Electrical Engineering – congrats Tal!
  • Our work has been featured in a Haaretz article about 3D genome organization!
  • New paper: “Attenuated chromatin compartmentalization in meiosis and its maturation in sperm development” – read here. On the cover of Nature Structural & Molecular Biology
NSMB cover

 

E-mail: noam.kaplan@technion.ac.il