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Genomes carry genetic information. But genomes are not just abstract information: they are physically manifested as extremely long molecules that are intricately organized in the nucleus of every cell. The spatial organization of the genome is closely related to how it is accessed, regulated and activated by cellular machinery. We are an interdisciplinary group studying this profound connection between genetic (and epigenetic) information and its physical organization. Our team includes researchers from diverse backgrounds including biology, chemical engineering, math, computer science, electrical engineering, physics and biotechnology.

Our research combines experimental and computational methods to gain a mechanistic understanding of how the genome encodes its organization and how this organization conveys biological function in various biological systems and diseases. Read more about our research here.

• New preprint: “Fast Low-Input Efficient Hi-C” – read here.
• New preprint: “Large-scale manipulation of radial positioning does not affect most aspects of genome organization” – read here.
• We have received a short-term research grant in collaboration with Prof. Sara Selig from the Rappaport Institute!
• Moran Tel-Paz has completed her MSc – congratulations!
• New paper in Communications Biology: “KMD clustering: robust general-purpose clustering of biological data” – read here.
• New updated preprint: “A genome-wide nucleosome-resolution map of promoter-centered interactions in human cells corroborates the enhancer-promoter looping model” – read here.
• New paper in Nucleic Acids Research: “Hypothesis-driven probabilistic modelling enables a principled perspective of genomic compartments” – read here.